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Numerical simulation of damage in high arch dam due to earthquake
Hong ZHONG , Gao LIN , Hongjun LI
《结构与土木工程前沿(英文)》 2009年 第3卷 第3期 页码 316-322 doi: 10.1007/s11709-009-0039-9
关键词: mesoscopic heterogeneity damage simulation in earthquakes arch dam
Heterogeneity of the tumor immune microenvironment and clinical interventions
《医学前沿(英文)》 2023年 第17卷 第4期 页码 617-648 doi: 10.1007/s11684-023-1015-9
用于介观模拟电子束选区熔化的数据挖掘技术 Article
钱亚, 闫文韬, 林峰
《工程(英文)》 2019年 第5卷 第4期 页码 746-754 doi: 10.1016/j.eng.2019.06.006
在电子束选区熔化技术(EBSM)工艺中,制造部件的性质受到每一道熔道沉积质量的影响。然而,熔道的形成受到各种物理现象和工艺参数的支配,这些参数之间的相关性十分复杂,难以通过实验得出。近来,介观建模技术已成为模拟电子束(EB)熔化过程以及揭示特定熔道形貌的形成机制的手段。尽管如此,人们对工艺参数与熔道特征之间的相关性尚未有定量的理解。本文从介观模拟的结果出发,研究了熔道的形态特征,同时引入了熔道宽度和高度等关键性描述指标,以便从数值上评估沉积质量。本文还定量研究了各种工艺参数的影响,从而导出了工艺条件和熔道特征之间的相关性。最后,本文提出了一种由介观建模和数据挖掘技术组成的仿真驱动优化框架,并讨论了框架的潜力和局限性。
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1060-1078 doi: 10.1007/s11705-021-2117-z
关键词: anchoring groups adsorption behaviour dye-binding strength squaraine dyes dye-sensitized solar cells
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 551-561 doi: 10.1007/s11684-020-0760-2
关键词: glioma evolution mechanism strategies tumor heterogeneity secondary glioma
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
Effect of catalyst layer mesoscopic pore-morphology on cold start process of PEM fuel cells
Ahmed Mohmed DAFALLA, Fangming JIANG
《能源前沿(英文)》 2021年 第15卷 第2期 页码 460-472 doi: 10.1007/s11708-021-0733-4
关键词: cold start energy conversion fuel cells mesoscale morphology tortuosity water management
Computational modeling of fracture in concrete: A review
Luthfi Muhammad Mauludin, Chahmi Oucif
《结构与土木工程前沿(英文)》 2020年 第14卷 第3期 页码 586-598 doi: 10.1007/s11709-020-0573-z
关键词: concrete fracture macroscopic micromechanical heterogeneity
Analysis of stress and failure in rock specimens with closed and open flaws on the surface
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1222-1237 doi: 10.1007/s11709-021-0773-1
关键词: surface flaw heterogeneity circular hole numerical modeling relative displacement
A multiscale material model for heterogeneous liquid droplets in solid soft composites
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1292-1299 doi: 10.1007/s11709-021-0771-3
关键词: liquid in solid soft composite computational modeling multiscale model heterogeneity
Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments
《工程管理前沿(英文)》 页码 550-562 doi: 10.1007/s42524-022-0193-5
关键词: COVID-19 masks behavioral heterogeneity asymptomatic infection
Mesoscopic properties of dense granular materials: An overview
Qicheng SUN, Feng JIN, Guohua ZHANG
《结构与土木工程前沿(英文)》 2013年 第7卷 第1期 页码 1-12 doi: 10.1007/s11709-013-0184-z
关键词: granular matter macroscopic structure jamming phase transition
Factors affecting the distribution of microplastics in soils of China
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1710-4
● Microplastic (MP) abundance in soil of China was highly heterogeneous.
关键词: Microplastic distribution Microplastic heterogeneity Effecting factors Agriculture Socio-economic factors
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 240-262 doi: 10.1007/s11684-022-0936-z
关键词: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 74-86 doi: 10.1007/s11684-017-0503-1
β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.
关键词: β-thalassemia long non-coding RNA mRNA phenotypic heterogeneity pathway
标题 作者 时间 类型 操作
Numerical simulation of damage in high arch dam due to earthquake
Hong ZHONG , Gao LIN , Hongjun LI
期刊论文
bottleneck of phosphonic acid anchoring groups aiming toward enhancing the stability and efficiency of mesoscopic
期刊论文
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
期刊论文
Effect of catalyst layer mesoscopic pore-morphology on cold start process of PEM fuel cells
Ahmed Mohmed DAFALLA, Fangming JIANG
期刊论文
Computational modeling of fracture in concrete: A review
Luthfi Muhammad Mauludin, Chahmi Oucif
期刊论文
Mesoscopic properties of dense granular materials: An overview
Qicheng SUN, Feng JIN, Guohua ZHANG
期刊论文